Summary   Summary
Featured Diseases & Conditions
Health Awareness Articles
Articles
Symptom Checker

Symptom Checker
Just click on a body part, choose your symptom and search through a world of health information.

 

Search Diseases

Search Disease

Cholestasis


Overview :

Cholestasis is caused by obstruction within the liver (intrahepatic) or outside the liver (extrahepatic). The obstruction causes bile salts, the bile pigment bilirubin, and fats (lipids) to accumulate in the blood stream instead of being eliminated normally.

Intrahepatic cholestasis is characterized by widespread blockage of small ducts or by disorders, such as hepatitis, that impair the body's ability to eliminate bile. Extrahepatic cholestasis can occur as a side effect of many medications. It can also occur as a complication of surgery, serious injury, tissue-destroying infection, or intravenous feeding. Extrahepatic cholestasis can be caused by conditions such as tumors and gallstones that block the flow of bile from the gallbladder to the first part of the small intestine (duodenum).

Pregnancy increases the sensitivity of the bile ducts to estrogen, and cholestasis often develops during the second and third trimesters of pregnancy. This condition is the second most common cause of jaundice during pregnancy, but generalized itching (pruritus gravidarum) is the only symptom most women experience. Cholestasis of pregnancy tends to run in families. Symptoms usually disappear within two to four weeks after the baby's birth but may reappear if the woman becomes pregnant again.

A similar condition affects some women who take birth control pills. Symptoms disappear after the woman stops using oral contraceptives. This condition does not lead to chronic liver disease. A woman who develops cholestasis from either of these causes (pregnancy or birth control hormones) has an increased risk of developing cholestasis from the other.

Benign familial recurrent cholestasis is a rare condition characterized by brief, repeated episodes of itching and jaundice. Symptoms often disappear. This condition does not cause cirrhosis.

Drug-induced cholestasis may be a complication of chemotherapy or other medications. The two major types of drug-induced cholestasis are direct toxic injury and reactions unique to an individual (idiosyncratic reactions). In direct toxic injury, the severity of symptoms parallels the amount of medication involved. This condition:

  • develops a short time after treatment begins
  • follows a predictable pattern
  • usually causes liver damage

Direct toxic reactions develop in 1% of all patients who take chlorpromazine (Thorazine), a tranquilizer and antinausea drug. Idiosyncratic reactions may occur at the onset of treatment or at a later time. Allergic responses are varied and are not related to the amount of medication being taken.




 Image Gallary
 
Search for information related to Health and wellness
Health Centers
Cardiology and HeartMen's HealthWomen's HealthMother + ChildDiabetesStressInfectious DiseaseSkinEyeCancerStop SmokingWeight ManagementSexual HealthBlood Pressure ManagementAsthmaPregnancy and Child BirthAllergyHair LossDengueCold and FluSore ThroatADHDDental & Oral HealthHigh CholesterolDepressionPolioBreast CancerFood PoisonSnoringConjunctivitisCervical CancerJaundiceGeneral HealthMigraine / HeadacheThyroidBlood SugarProstate CancerKidney DiseaseAnxietyArthritisAutismBipolar DisorderCOPDCaregivingCrohn's DiseaseEpilepsyErectile DysfunctionHealthy AgingIncontinenceMeningitisMenopauseMultiple SclerosisOsteoporosisPain ManagementParkinson's DiseaseRelationshipsSleep ManagementStomach & DigestiveOsteoarthritisPertussisOveractive BladderRheumatoid ArthritisTonsils
Search for information related to Health and wellness
 
Health Pages
blood pressure cancer cholesterol test diabetes diets erectile dysfunction hair loss health health articles healthy living heart diseases high cholesterol pregnancy reduce weight vagina weight wellness health plan sexual problems lower cholesterol heart attack women health asthma weight loss anxiety back problems disease symptoms immunization for children indian home remedies indian recipes Manage weight pathology tests stress simona halep breasts What Do You Have To Say About Us triglycerides ranges sinus infection and tooth pain std diseases massages community atlantic health breast staging Pelvic Inflammatory Disease cholesterol fighting foods niacin lower cholesterol sylvester cancer center kicks against breast cancer penis removal