Summary   Summary
Featured Diseases & Conditions
Health Awareness Articles
Symptom Checker

Symptom Checker
Just click on a body part, choose your symptom and search through a world of health information.


Search Diseases

Search Disease


Overview :

Gastrinomas are an integral part of the Zollinger-Ellison syndrome (ZES). In fact, ZES is also known as gastrinoma. This syndrome consists of ulcer disease in the upper gastrointestinal tract, marked increases in the secretion of gastric acid in the stomach, and tumors of the islet cells in the pancreas. The tumors produce large amounts of gastrin that are responsible for the characteristics of Zollinger-Ellison syndrome, namely severe ulcer disease. Although usually located within the pancreas, they may occur in other organs.

Gastrinomas may occur randomly and sporadically, or they may be inherited as part of a genetic condition called multiple endocrine neoplasia type 1 (MEN-1) syndrome. About half of persons with MEN-1 have gastrinomas, which tend to be more numerous and smaller than tumors in sporadic cases.

About half of ZES patients have multiple gastrinomas, which can vary in size from 1-20 mm. Gastrinomas found in the pancreas are usually much larger than duodenal gastrinomas. About two thirds of gastrinomas are malignant (cancerous). These usually grow slowly, but some may invade surrounding sites rapidly and metastasize (spread) widely. Sometimes, gastrinomas are found only in the lymph nodes, and it is uncertain whether these malignancies have originated in the lymph nodes or have metastasized from a tumor not visible in the pancreas or duodenum.

There is some evidence that the more malignant form of gastrinomas is more frequent in larger pancreatic tumors, especially in females and in persons with a shorter disease symptom duration and higher serum gastrin levels.

 Image Gallary
Search for information related to Health and wellness
Health Centers
Cardiology and HeartMen's HealthWomen's HealthMother + ChildDiabetesStressInfectious DiseaseSkinEyeCancerStop SmokingWeight ManagementSexual HealthBlood Pressure ManagementAsthmaPregnancy and Child BirthAllergyHair LossDengueCold and FluSore ThroatADHDDental & Oral HealthHigh CholesterolDepressionPolioBreast CancerFood PoisonSnoringConjunctivitisCervical CancerJaundiceGeneral HealthMigraine / HeadacheThyroidBlood SugarProstate CancerKidney DiseaseAnxietyArthritisAutismBipolar DisorderCOPDCaregivingCrohn's DiseaseEpilepsyErectile DysfunctionHealthy AgingIncontinenceMeningitisMenopauseMultiple SclerosisOsteoporosisPain ManagementParkinson's DiseaseRelationshipsSleep ManagementStomach & DigestiveOsteoarthritisPertussisOveractive BladderRheumatoid ArthritisTonsils
Search for information related to Health and wellness
Health Pages
blood pressure cancer cholesterol test diabetes diets erectile dysfunction hair loss health health articles healthy living heart diseases high cholesterol pregnancy reduce weight vagina weight wellness health plan sexual problems lower cholesterol heart attack women health asthma weight loss anxiety back problems disease symptoms immunization for children indian home remedies indian recipes Manage weight pathology tests stress about aceclofenac depression problems breast feeding videos breast plate effects of breast cancer cholesterol control diet free pregnancy testing dental office stop swine flu walnuts heart health glucose level for diabetes impotent man cancer doctor high cholesterol high triglycerides abortions facts