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Hepatitis C


Overview :

HCV is a blood-borne virus that is and always was the major cause of "transfusion hepatitis," which can develop in patients who are given blood or most blood products except for gamma-globulin. The existence of a third hepatitis virus (besides the A and B viruses) became clear in 1974, but HCV was first identified in 1989. Thereafter, tests were devised to detect the virus in blood units before transfusing them. As a result, since the early 1990s transfused blood is less commonly the cause of hepatitis C.

The hepatitis C form of hepatitis is generally mild in its early, acute stage, but it is much likelier than hepatitis B (85% as compared to 10%) to produce chronic liver disease. Therefore, more than two of every three persons who are infected by HCV may continue to have the virus in their blood and so become carriers, who can transmit the infection to others.

The most common way of transmitting hepatitis C is when blood containing the virus enters another person's circulation through a break in the skin or the mucosa (inner lining) of the mouth or genitals. HCV also can be passed (although uncommonly) from an infected mother to the infant she is carrying. (The risk of infection from breast milk is very low.) Also, HCV can be rarely spread through sexual intercourse. Usually, however, the sexual contacts of chronic carriers of hepatitis C are not infected.

Those at increased risk of developing hepatitis C include:

  • healthcare workers who come in contact with infected blood from a cut or bruise, or from a device or instrument that has been infected ("contaminated")
  • persons who inject illicit drugs into their veins and skin, especially if they share needles and syringes with other users
  • anyone who gets a tattoo or has his or her skin pierced with an infected needle
  • persons with hemophilia (who because they bleed very easily may require large amounts of blood and blood products over time)
  • patients with kidney disease who have periodic dialysis—a treatment that rids their blood of toxic substances—and often requires the patient to have blood transfusions

About one-fourth of patients with hepatitis C do not belong to any of these high-risk groups. Although blood transfusion is a much less common cause of HCV infection than in earlier years, cases still occur. Also, sexual transmission is possible, and may take place with either heterosexual or homosexual behavior.




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