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Leukotriene Inhibitors


Overview :

Leukotriene inhibitors are often called leukotriene:

  • blockers
  • modifiers
  • antagonists
  • pathway modifiers

When they were first introduced in 1996, leukotriene inhibitors represented the first new class of asthma medication in two decades. Classified as anti-inflammatories, they were originally developed to improve lung function in asthmatics by relaxing the smooth muscles around the bronchial airways and by reducing lung inflammation.

Types of leukotriene inhibitors

The available leukotriene inhibitors are: montelukast (Singulair), zafirlukast (Accolate), and zileuton (Zyflo).

Montelukast and zafirlukast are leukotriene-receptor antagonists that prevent leukotriene from binding to cell receptors and initiating the chain of events leading to symptoms of allergy and asthma. Montelukast works rapidly. It is the only leukotriene inhibitor that has been approved by the U.S. Food and Drug Administration (FDA) for use in children as young as two, as well as for the treatment of seasonal allergies.

Zafirlukast is a synthetic peptide that inhibits the receptor binding of three leukotreines (LTC4, LTD4, and LTE4) that cause smooth muscle constriction. It is used for mild to moderate persistent asthma, exercise-induced asthma, and the management of allergic rhinitis in those aged seven and older.

Zileuton is a 5-lipooxygenase pathway inhibitor that interferes with the synthesis of LTA4, LTC4, LTD4, and LTE4. It is used to treat chronic asthma in adolescents and adults./p>




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