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Osteopetroses


Overview :

Osteopetrosis occurs when bones are spongy or porous, or new bone is repeatedly added to calcified cartilage (hardened connective tissue).

Bone density begins to increase at birth or earlier, but symptoms may not become evident until adulthood. In mild cases, bone density increases at gradual, irregular intervals until full adult height is attained. Some bones are not affected.

More severe osteopetrosis progresses at a rapid pace and destroys bone structure. This condition involves bones throughout the body, but the lower jaw is never affected.

Types of osteopetroses

In early-onset osteopetrosis ends of the long bones of the arms and legs appear clubbed (widened and thickened) at birth, and bone density continues to increase sporadically or without pause. Early-onset osteopetroses can be a fatal condition, resulting in death before the age of two.

Malignant infantile osteopetrosis is most often discovered by the time a baby is a few months old. One-third of all malignant infantile osteopetroses cases result in death before the age of 10.

Intermediate osteopetrosis generally appears in children under 10. This condition, usually less severe than early-onset or malignant infantile osteopetrosis, is not life-threatening.

Symptoms of adult or delayed-onset osteopetrosis may not become evident until the child becomes a teenager or adult.

Relatively common in many parts of the world, Albers-Schönberg disease is a mild form of this condition. People who have this disease are born with normal bone structure. Bone density increases as they age but does not affect appearance, health, intelligence, or life span.




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